Posted by Catherline Ng
on November 17, 2025
Skin brightness, texture, and hair density may look like external concerns, but they actually reflect how well cells maintain their metabolic rhythm. When this rhythm slows down and aging components cannot be cleared, skin becomes dull and hair follicles lose vitality. Spermidine helps restore this balance by promoting autophagy and supporting cellular renewal.
1. Spermidine Supports Skin Renewal Through Autophagy
The skin renews quickly, but during this process, it continuously produces aging mitochondria, oxidized proteins and damaged cell fragments. If these waste products are not removed, they block normal cellular function, slow repair, and dull the skin.
Autophagy is the cell’s natural cleaning system. It uses the lysosomal pathway to clear damaged cellular components, keeping the internal environment clean. However, with aging or UV exposure, autophagy activity decreases, leading to:
- Accumulation of damaged organelles and misfolded proteins
- Impaired fibroblast function and reduced collagen production
- Weakened skin barrier and slower repair
Spermidine, a natural polyamine, helps restore this process.
How Spermidine Enhances Autophagy:
- Activates autophagy-related genes such as LC3, Beclin-1, and ATG5 by improving chromatin accessibility
- Supports AMPK and SIRT1 activity, which maintain mitochondrial renewal and cellular repair efficiency
- Relieves mTOR suppression, allowing cells to resume their natural cleaning mode instead of only focusing on synthesis
When autophagy resumes, fibroblasts restore their ability to synthesize collagen and elastin. Studies show spermidine can up-regulate COL1A1 and COL3A1, supporting dermal structure and barrier repair.
2. Extends Hair Follicle Growth Phase and Protects Stem Cells
Hair follicles cycle through anagen (growth), catagen (regression) and telogen (resting). Hair density depends largely on how long follicles stay in the anagen phase. Spermidine supports this cycle by protecting stem cells and activating growth pathways.
Key Actions in Hair Follicles:
- Activates hair growth signals
Increases VEGF for better microcirculation and enhances the beta-catenin pathway, which is essential for maintaining the anagen phase. - Protects follicular stem cells
It helps retain stemness by boosting K15 and K19 expression, preventing premature aging or differentiation of stem cells.
Clinical Evidence
In a 90-day randomized, double-blind, placebo-controlled study with 100 adults:
- Spermidine group: more than 50% increase in hair bulbs in the anagen phase
- Placebo group: approximately 20% decrease in anagen hair follicles
When cells regain their ability to renew and repair, you begin to see visible improvements: smoother texture, improved resilience, and naturally fuller hair. These changes occur gradually but reflect deep cellular revitalization.
BIGVITA uses Yüth™ Spermidine with over 98% purity. It supports autophagy, optimizes energy metabolism inside cells and helps maintain firmer, radiant skin and fuller hair.
Summary
Spermidine is not just a surface-level solution. By enhancing autophagy, protecting follicular stem cells and supporting cellular energy balance, it helps skin and hair regain their inherent ability to renew, repair and stay youthful from within. Youth+, powered by Yüth™ Spermidine, offers a science-backed way to support this cellular renewal process—helping skin and hair maintain a smoother, stronger and more resilient appearance over time.
Ready to feel how renewal starts from within?
Explore Youth+ with Yüth™ Spermidine and discover your skin and hair’s real potential. →
Reference:
1. Bergamini, E. (2006). Molecular Aspects of Medicine, 27(5–6), 403–410.
Hörl, S., et al. (2021). Nature Aging, 1(9), 885–899.
2. Jeong, D., et al. (2020). Journal of Investigative Dermatology, 140(9), 1691–1697.
3. Ramot, Y., et al. (2009). FASEB Journal, 23(11), 393-404.
4. Mokhtari, Y., et al. (2021). Communications Biology, 4, Article 231.
5. Rinaldi, F., et al. (2017). Dermatology Practical & Conceptual, 7(4), 17–21.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Results vary by individual.
The information on this website is for general educational purposes and not a substitute for medical advice.
